ATP2B3

From Wikipedia, the free encyclopedia

ATPase, Ca++ transporting, plasma membrane 3

Identifiers

External IDs

OMIM: 300014 MGI: 1347353 HomoloGene: 49690

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • calcium-transporting ATPase activity • calcium ion binding • calmodulin binding • ATP binding • hydrolase activity • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Cellular Component:	• plasma membrane • integral to membrane
Biological Process:	• cation transport • calcium ion transport • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001001344 (mRNA)
NP_001001344 (protein)

NM_177236 (mRNA)
NP_796210 (protein)

Location

Chr X: 152.44 - 152.5 Mb

Chr X: 69.76 - 69.82 Mb

Pubmed search

[1]

[2]

ATPase, Ca++ transporting, plasma membrane 3, also known as ATP2B3, is a human gene.^[1]

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: ATP2B3 ATPase, Ca++ transporting, plasma membrane 3.

[edit] Further reading

Møller JV, Juul B, le Maire M (1996). "Structural organization, ion transport, and energy transduction of P-type ATPases.". Biochim. Biophys. Acta 1286 (1): 1–51. PMID 8634322.
Strehler EE, Zacharias DA (2001). "Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.". Physiol. Rev. 81 (1): 21–50. PMID 11152753.
Strehler EE, Treiman M (2004). "Calcium pumps of plasma membrane and cell interior.". Curr. Mol. Med. 4 (3): 323–35. PMID 15101689.
Brandt P, Neve RL, Kammesheidt A, et al. (1992). "Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels.". J. Biol. Chem. 267 (7): 4376–85. PMID 1531651.
Stauffer TP, Hilfiker H, Carafoli E, Strehler EE (1995). "Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.". J. Biol. Chem. 269 (50): 32022. PMID 7989379.
Wang MG, Yi H, Hilfiker H, et al. (1994). "Localization of two genes encoding plasma membrane Ca2+ ATPases isoforms 2 (ATP2B2) and 3 (ATP2B3) to human chromosomes 3p26-->p25 and Xq28, respectively.". Cytogenet. Cell Genet. 67 (1): 41–5. PMID 8187550.
Stauffer TP, Hilfiker H, Carafoli E, Strehler EE (1994). "Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.". J. Biol. Chem. 268 (34): 25993–6003. PMID 8245032.
Brown BJ, Hilfiker H, DeMarco SJ, et al. (1996). "Primary structure of human plasma membrane Ca(2+)-ATPase isoform 3.". Biochim. Biophys. Acta 1283 (1): 10–3. PMID 8765088.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Mallon AM, Platzer M, Bate R, et al. (2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man.". Genome Res. 10 (6): 758–75. PMID 10854409.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Moreau R, Daoud G, Masse A, et al. (2004). "Expression and role of calcium-ATPase pump and sodium-calcium exchanger in differentiated trophoblasts from human term placenta.". Mol. Reprod. Dev. 65 (3): 283–8. doi:10.1002/mrd.10303. PMID 12784250.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Martin R, Harvey NC, Crozier SR, et al. (2007). "Placental calcium transporter (PMCA3) gene expression predicts intrauterine bone mineral accrual.". Bone 40 (5): 1203–8. doi:10.1016/j.bone.2006.12.060. PMID 17336174.