Apoptosis-inducing factor

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programmed cell death 8 (apoptosis-inducing factor)
Identifiers
Symbol	PDCD8
Entrez	9131
HUGO	8768
OMIM	300169
RefSeq	NM_004208
UniProt	O95831
Other data
Locus	Chr. X q25-q26

Apoptosis inducing factor is a flavoprotein.

Apoptosis inducing factor is involved in initiating a caspase-independent pathway of apoptosis (positive intrinsic regulator of apoptosis) by causing DNA fragmentation and chromatin condensation. It also acts as an NADH oxidase. Another AIF function is to regulate the permeability of the mitochondrial membrane upon apoptosis. Normally it is found behind the outer membrane of the mitochondria and is therefore secluded from the nucleus. However, when the mitochondria is damaged, it moves to the cytosol and to the nucleus. Inactivation of AIF leads to resistance of embryonic stem cells to death following the withdrawal of growth factors indicating that it is involved in apoptosis.

[edit] See also

• Apoptosis

[edit] External links

• MeSH Apoptosis+inducing+factor

http://www.mitochondrial.net/showabstract.php?pmid=12022952

Template:Cell-signaling-stub

v • d • e Protein: flavoproteins Acetolactate synthase - Acyl CoA dehydrogenase - Apoptosis-inducing factor - Butyryl CoA dehydrogenase - Cryptochrome - Cytochrome b5 reductase - Dihydrolipoamide dehydrogenase - Flavodoxin - Methemoglobin reductase - Methylenetetrahydrofolate reductase - NADH dehydrogenase - NADPH oxidase - Nitrate reductase - Sarcosine oxidase - Thioredoxin reductase