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The subiculum (Latin for "support") is the most inferior component of the hippocampal formation. It lies between the entorhinal cortex and the CA1 subfield of the hippocampus proper.
It receives input from CA1 and entorhinal cortical layer III pyramidal neurons and is the main output of the hippocampus. The pyramidal neurons send projections to the nucleus accumbens, septal nuclei, prefrontal cortex, hypothalamus, entorhinal cortex and amygdala.
The pyramidal neurons in the subiculum exhibit transitions between two modes of action potential output: bursting and single spiking. The transitions between these two modes is thought to be important for routing information out of the hippocampus.
It is the site responsible for ictal activity in some cases of human epilepsy. It has also been implicated in working memory and drug addiction.
[edit] References
- "Switching Signals in the Brain," PLoS Biology, 3(6):e210, 2005 June.
- Donald C. Cooper, Sungkwon Chung, Nelson Spruston, "Output-Mode Transitions Are Controlled by Prolonged Inactivation of Sodium Channels in Pyramidal Neurons of Subiculum," PLoS Biology, 3(6):e175, 2005 June.
- Donald C. Cooper, Shannon J. Moore, Nathan P. Staff, and Nelson Spruston, "Psychostimulant-induced plasticity of intrinsic excitability in the ventral subiculum," Journal of Neuroscience, October 29, 2003, 23(30):9937-9946
[edit] External links
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