SORD

From Wikipedia, the free encyclopedia

Sorbitol dehydrogenase

PDB rendering based on 1pl6.

Available structures: 1pl6, 1pl7, 1pl8

Identifiers

Symbol(s)

SORD; SORD1

External IDs

OMIM: 182500 MGI: 98266 HomoloGene: 55715

Gene ontology
Molecular Function:	• L-iditol 2-dehydrogenase activity • zinc ion binding • oxidoreductase activity • metal ion binding
Biological Process:	• sorbitol metabolic process • visual perception

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001132175 (mRNA)
XP_001132175 (protein)

NM_146126 (mRNA)
NP_666238 (protein)

Location

Chr 15: 43.1 - 43.15 Mb

Chr 2: 121.93 - 121.96 Mb

Pubmed search

[1]

[2]

Sorbitol dehydrogenase, also known as SORD, is a human gene.^[1]

[edit] References

^ Entrez Gene: SORD sorbitol dehydrogenase.

[edit] Further reading

El-Kabbani O, Darmanin C, Chung RP (2004). "Sorbitol dehydrogenase: structure, function and ligand design.". Curr. Med. Chem. 11 (4): 465-76. PMID 14965227.
Karlsson C, Maret W, Auld DS, et al. (1990). "Variability within mammalian sorbitol dehydrogenases. The primary structure of the human liver enzyme.". Eur. J. Biochem. 186 (3): 543-50. PMID 2691249.
Samanta BK, Chandra NC, Ghosh S, Mukherjee KL (1985). "Aldose metabolism in developing human fetal brain and liver.". Experientia 40 (12): 1420-2. PMID 6439573.
Lee FK, Lee AY, Lin CX, et al. (1995). "Cloning, sequencing, and determination of the sites of expression of mouse sorbitol dehydrogenase cDNA.". Eur. J. Biochem. 230 (3): 1059-65. PMID 7601136.
Iwata T, Popescu NC, Zimonjic DB, et al. (1995). "Structural organization of the human sorbitol dehydrogenase gene (SORD).". Genomics 26 (1): 55-62. PMID 7782086.
Lee FK, Cheung MC, Chung S (1994). "The human sorbitol dehydrogenase gene: cDNA cloning, sequence determination, and mapping by fluorescence in situ hybridization.". Genomics 21 (2): 354-8. doi:10.1006/geno.1994.1276. PMID 8088829.
Alvarez A, Martínez A, Ibarra B, et al. (1993). "Membrane-bound sorbitol dehydrogenase in human red blood cells. Studies in normal subjects and in enzyme-deficient subjects with congenital cataracts.". J. Inherit. Metab. Dis. 16 (1): 67-72. PMID 8487505.
Carr IM, Markham AF, Coletta PL (1997). "Identification and characterisation of a sequence related to human sorbitol dehydrogenase.". Eur. J. Biochem. 245 (3): 760-7. PMID 9183016.
Carr IM, Whitehouse A, Coletta PL, Markham AF (1999). "Structural and evolutionary characterization of the human sorbitol dehydrogenase gene duplication.". Mamm. Genome 9 (12): 1042-8. PMID 9880675.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Darmanin C, Iwata T, Carper DA, et al. (2003). "Expression, purification and preliminary crystallographic analysis of human sorbitol dehydrogenase.". Acta Crystallogr. D Biol. Crystallogr. 59 (Pt 3): 558-60. PMID 12595725.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.
Pauly TA, Ekstrom JL, Beebe DA, et al. (2004). "X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase.". Structure 11 (9): 1071-85. PMID 12962626.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.". J. Steroid Biochem. Mol. Biol. 94 (1-3): 203-8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Klimacek M, Hellmer H, Nidetzky B (2007). "Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.". Biochem. J. 404 (3): 421-9. doi:10.1042/BJ20061384. PMID 17343568.