RPL4

From Wikipedia, the free encyclopedia

Ribosomal protein L4

Identifiers

External IDs

OMIM: 180479 MGI: 1915141 HomoloGene: 748

Gene ontology
Molecular Function:	• RNA binding • structural constituent of ribosome • protein binding
Cellular Component:	• intracellular • ribosome • cytosolic large ribosomal subunit (sensu Eukaryota)
Biological Process:	• translation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000968 (mRNA)
NP_000959 (protein)

NM_024212 (mRNA)
NP_077174 (protein)

Location

Chr 15: 64.58 - 64.6 Mb

Chr 9: 63.97 - 63.98 Mb

Pubmed search

[1]

[2]

Ribosomal protein L4, also known as RPL4, is a human gene.^[1]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L4E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[1]

[edit] References

^ ^a ^b Entrez Gene: RPL4 ribosomal protein L4.

[edit] Further reading

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11-12): 933–47. PMID 8722009.
Chan YL, Olvera J, Wool IG (1995). "The primary structures of rat ribosomal proteins L4 and L41.". Biochem. Biophys. Res. Commun. 214 (3): 810–8. doi:10.1006/bbrc.1995.2359. PMID 7575549.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Bagni C, Mariottini P, Annesi F, Amaldi F (1994). "Human ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein.". Biochim. Biophys. Acta 1216 (3): 475–8. PMID 8268230.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes.". Genome Res. 8 (5): 509–23. PMID 9582194.
Twiss JL, Smith DS, Chang B, Shooter EM (2000). "Translational control of ribosomal protein L4 mRNA is required for rapid neurite regeneration.". Neurobiol. Dis. 7 (4): 416–28. doi:10.1006/nbdi.2000.0293. PMID 10964612.
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders.". Genomics 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298.
Jäkel S, Mingot JM, Schwarzmaier P, et al. (2002). "Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains.". EMBO J. 21 (3): 377–86. doi:10.1093/emboj/21.3.377. PMID 11823430.
Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMID 11875025.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. PMID 14667819.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.". Mol. Cell Proteomics 6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.