RCN2
From Wikipedia, the free encyclopedia
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Reticulocalbin 2, EF-hand calcium binding domain
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| Identifiers | |||||||||||
| Symbol(s) | RCN2; E6BP; ERC-55; ERC55 | ||||||||||
| External IDs | OMIM: 602584 MGI: 1349765 HomoloGene: 2176 | ||||||||||
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| RNA expression pattern | |||||||||||
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| Orthologs | |||||||||||
| Human | Mouse | ||||||||||
| Entrez | 5955 | 26611 | |||||||||
| Ensembl | ENSG00000117906 | ENSMUSG00000032320 | |||||||||
| Uniprot | Q14257 | Q3TE95 | |||||||||
| Refseq | NM_002902 (mRNA) NP_002893 (protein) |
NM_011992 (mRNA) NP_036122 (protein) |
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| Location | Chr 15: 75.01 - 75.03 Mb | Chr 9: 55.84 - 55.86 Mb | |||||||||
| Pubmed search | [1] | [2] | |||||||||
Reticulocalbin 2, EF-hand calcium binding domain, also known as RCN2, is a human gene.[1]
Reticulocalbin 2 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. The RCN2 gene maps to the same region as type 4 Bardet-Biedl syndrome (MIM:600374), suggesting a possible causative role for reticulocalbin 2 in the disorder.[1]
[edit] References
[edit] Further reading
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:. PMID 15489334.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:. PMID 14743216.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:. PMID 12477932.
- Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS (2000). "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2.". J. Biol. Chem. 275 (23): 17786-92. doi:. PMID 10748068.
- Wang JY, Zhen DK, Bianchi DW, et al. (1998). "Assignment of the gene for ERC-55 (RCN2) to human chromosome band 15q22.33-->q24.1 by in situ hybridization.". Cytogenet. Cell Genet. 79 (1-2): 60-1. PMID 9533013.
- Dodds DC, Omeis IA, Cushman SJ, et al. (1997). "Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49.". J. Biol. Chem. 272 (34): 21488-94. PMID 9261167.
- Weis K, Griffiths G, Lamond AI (1994). "The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif.". J. Biol. Chem. 269 (29): 19142-50. PMID 8034671.
- Chen JJ, Reid CE, Band V, Androphy EJ (1995). "Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein.". Science 269 (5223): 529-31. PMID 7624774.
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