PSTPIP1

From Wikipedia, the free encyclopedia

Proline-serine-threonine phosphatase interacting protein 1

PDB rendering based on 2dil.

Available structures: 2dil

Identifiers

Symbol(s)

PSTPIP1; CD2BP1; CD2BP1L; CD2BP1S; H-PIP; PAPAS; PSTPIP

External IDs

OMIM: 606347 MGI: 1321396 HomoloGene: 37867

Gene ontology
Molecular Function:	• actin binding • protein binding • protein phosphatase binding
Cellular Component:	• stress fiber • contractile ring
Biological Process:	• cell adhesion • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003978 (mRNA)
NP_003969 (protein)

NM_011193 (mRNA)
NP_035323 (protein)

Location

Chr 15: 75.07 - 75.12 Mb

Chr 9: 55.89 - 55.93 Mb

Pubmed search

[1]

[2]

Proline-serine-threonine phosphatase interacting protein 1, also known as PSTPIP1, is a human gene.^[1]

[edit] References

^ Entrez Gene: PSTPIP1 proline-serine-threonine phosphatase interacting protein 1.

[edit] Further reading

Spencer S, Dowbenko D, Cheng J, et al. (1997). "PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase.". J. Cell Biol. 138 (4): 845–60. PMID 9265651.
Dowbenko D, Spencer S, Quan C, Lasky LA (1998). "Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein.". J. Biol. Chem. 273 (2): 989–96. PMID 9422760.
Wu Y, Spencer SD, Lasky LA (1998). "Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott-Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein.". J. Biol. Chem. 273 (10): 5765–70. PMID 9488710.
Wu Y, Dowbenko D, Lasky LA (1998). "PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase.". J. Biol. Chem. 273 (46): 30487–96. PMID 9804817.
Li J, Nishizawa K, An W, et al. (1999). "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion.". EMBO J. 17 (24): 7320–36. doi:10.1093/emboj/17.24.7320. PMID 9857189.
Cong F, Spencer S, Côté JF, et al. (2001). "Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation.". Mol. Cell 6 (6): 1413–23. PMID 11163214.
Oda A, Ochs HD, Lasky LA, et al. (2001). "CrkL is an adapter for Wiskott-Aldrich syndrome protein and Syk.". Blood 97 (9): 2633–9. PMID 11313252.
Côté JF, Chung PL, Théberge JF, et al. (2002). "PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP.". J. Biol. Chem. 277 (4): 2973–86. doi:10.1074/jbc.M106428200. PMID 11711533.
Wise CA, Gillum JD, Seidman CE, et al. (2003). "Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder.". Hum. Mol. Genet. 11 (8): 961–9. PMID 11971877.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Badour K, Zhang J, Shi F, et al. (2003). "The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse.". Immunity 18 (1): 141–54. PMID 12530983.
Shoham NG, Centola M, Mansfield E, et al. (2004). "Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway.". Proc. Natl. Acad. Sci. U.S.A. 100 (23): 13501–6. doi:10.1073/pnas.2135380100. PMID 14595024.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Baum W, Kirkin V, Fernández SB, et al. (2006). "Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL.". J. Biol. Chem. 280 (48): 40012–24. doi:10.1074/jbc.M502222200. PMID 16204241.
Yang H, Reinherz EL (2006). "CD2BP1 modulates CD2-dependent T cell activation via linkage to protein tyrosine phosphatase (PTP)-PEST.". J. Immunol. 176 (10): 5898–907. PMID 16670297.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.