PIGB

From Wikipedia, the free encyclopedia

Phosphatidylinositol glycan anchor biosynthesis, class B

Identifiers

PIGB; MGC21236

External IDs

OMIM: 604122 MGI: 1891825 HomoloGene: 3570

Gene ontology
Molecular Function:	• mannosyltransferase activity • transferase activity, transferring glycosyl groups
Cellular Component:	• endoplasmic reticulum • endoplasmic reticulum membrane • membrane • integral to membrane
Biological Process:	• protein amino acid glycosylation • GPI anchor biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004855 (mRNA)
NP_004846 (protein)

NM_018889 (mRNA)
NP_061377 (protein)

Location

Chr 15: 53.4 - 53.44 Mb

Chr 9: 72.81 - 72.84 Mb

Pubmed search

[1]

[2]

Phosphatidylinositol glycan anchor biosynthesis, class B, also known as PIGB, is a human gene.^[1]

This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases.^[1]

[edit] References

^ ^a ^b Entrez Gene: PIGB phosphatidylinositol glycan anchor biosynthesis, class B.

[edit] Further reading

Mohney RP, Knez JJ, Ravi L, et al. (1994). "Glycoinositol phospholipid anchor-defective K562 mutants with biochemical lesions distinct from those in Thy-1- murine lymphoma mutants.". J. Biol. Chem. 269 (9): 6536-42. PMID 7907094.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Takahashi M, Inoue N, Ohishi K, et al. (1996). "PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor.". EMBO J. 15 (16): 4254-61. PMID 8861954.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Anikster Y, Huizing M, Anderson PD, et al. (2002). "Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A.". Am. J. Hum. Genet. 71 (2): 407-14. PMID 12058346.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.