MRPS5

From Wikipedia, the free encyclopedia

Mitochondrial ribosomal protein S5

Identifiers

MRPS5; MRP-S5

External IDs

MGI: 1924971 HomoloGene: 32726

Gene ontology
Molecular Function:	• RNA binding • structural constituent of ribosome
Cellular Component:	• intracellular • mitochondrion • ribosome
Biological Process:	• translation

Orthologs

Human

Mouse

Refseq

NM_031902 (mRNA)
NP_114108 (protein)

NM_029963 (mRNA)
NP_084239 (protein)

Location

Chr 2: 95.12 - 95.15 Mb

Chr 2: 127.28 - 127.3 Mb

Pubmed search

[1]

[2]

Mitochondrial ribosomal protein S5, also known as MRPS5, is a human gene.^[1]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q.^[1]

[edit] References

^ ^a ^b Entrez Gene: MRPS5 mitochondrial ribosomal protein S5.

[edit] Further reading

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.". Genomics 81 (5): 468-80. PMID 12706105.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.". Genomics 77 (1-2): 65-70. doi:10.1006/geno.2001.6622. PMID 11543634.
Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit.". J. Biol. Chem. 276 (35): 33181-95. doi:10.1074/jbc.M103236200. PMID 11402041.
Koc EC, Burkhart W, Blackburn K, et al. (2001). "Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach.". Protein Sci. 10 (3): 471-81. PMID 11344316.
Cavdar Koc E, Burkhart W, Blackburn K, et al. (2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present.". J. Biol. Chem. 276 (22): 19363-74. doi:10.1074/jbc.M100727200. PMID 11279123.