MRPL22
From Wikipedia, the free encyclopedia
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Mitochondrial ribosomal protein L22
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| PDB rendering based on 2ftc. | ||||||||||||||
| Available structures: 2ftc | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | MRPL22; DKFZp781F1071; HSPC158; MRP-L25; RPML25 | |||||||||||||
| External IDs | MGI: 1333794 HomoloGene: 56664 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 29093 | 216767 | ||||||||||||
| Ensembl | ENSG00000082515 | ENSMUSG00000020514 | ||||||||||||
| Uniprot | Q9NWU5 | Q8BU88 | ||||||||||||
| Refseq | NM_001014990 (mRNA) NP_001014990 (protein) |
NM_175001 (mRNA) NP_778166 (protein) |
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| Location | Chr 5: 154.3 - 154.33 Mb | Chr 11: 57.99 - 58 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Mitochondrial ribosomal protein L22, also known as MRPL22, is a human gene.[1]
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene.[1]
[edit] References
[edit] Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
- Goldschmidt-Reisin S, Kitakawa M, Herfurth E, et al. (1999). "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences.". J. Biol. Chem. 273 (52): 34828-36. PMID 9857009.
- Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546-60. PMID 11042152.
- Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.". Genomics 77 (1-2): 65-70. doi:. PMID 11543634.
- Koc EC, Burkhart W, Blackburn K, et al. (2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.". J. Biol. Chem. 276 (47): 43958-69. doi:. PMID 11551941.
- O'Brien TW (2002). "Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease.". Gene 286 (1): 73-9. PMID 11943462.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:. PMID 12477932.
- Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.". Genomics 81 (5): 468-80. PMID 12706105.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:. PMID 15489334.
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