Cofilin 1

From Wikipedia, the free encyclopedia

Cofilin 1 (non-muscle)

PDB rendering based on 1q8g.

Available structures: 1q8g, 1q8x

Identifiers

Symbol(s)

CFL1; CFL

External IDs

OMIM: 601442 MGI: 101757 HomoloGene: 39624

Gene ontology
Molecular Function:	• actin binding • protein binding
Cellular Component:	• intracellular • nucleus • cytoplasm • cytoskeleton
Biological Process:	• anti-apoptosis • Rho protein signal transduction • actin cytoskeleton organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005507 (mRNA)
NP_005498 (protein)

XM_979959 (mRNA)
XP_985053 (protein)

Location

Chr 11: 65.38 - 65.38 Mb

Chr 19: 5.49 - 5.5 Mb

Pubmed search

[1]

[2]

Cofilin 1 (non-muscle), also known as CFL1, is a human gene.

Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM]^[1]

[edit] References

^ Entrez Gene: CFL1 cofilin 1 (non-muscle).

[edit] Further reading

Maciver SK, Hussey PJ (2002). "The ADF/cofilin family: actin-remodeling proteins.". Genome Biol. 3 (5): reviews3007. PMID 12049672.
Samstag Y, Nebl G (2004). "Interaction of cofilin with the serine phosphatases PP1 and PP2A in normal and neoplastic human T lymphocytes.". Adv. Enzyme Regul. 43: 197–211. PMID 12791392.
Ogawa K, Tashima M, Yumoto Y, et al. (1991). "Coding sequence of human placenta cofilin cDNA.". Nucleic Acids Res. 18 (23): 7169. PMID 2263493.
van der Steege G, Draaijers TG, Grootscholten PM, et al. (1995). "A provisional transcript map of the spinal muscular atrophy (SMA) critical region.". Eur. J. Hum. Genet. 3 (2): 87–95. PMID 7552146.
Davidson MM, Haslam RJ (1994). "Dephosphorylation of cofilin in stimulated platelets: roles for a GTP-binding protein and Ca2+.". Biochem. J. 301 ( Pt 1): 41–7. PMID 8037689.
Ono S, Minami N, Abe H, Obinata T (1994). "Characterization of a novel cofilin isoform that is predominantly expressed in mammalian skeletal muscle.". J. Biol. Chem. 269 (21): 15280–6. PMID 8195165.
Abe H, Nagaoka R, Obinata T (1993). "Cytoplasmic localization and nuclear transport of cofilin in cultured myotubes.". Exp. Cell Res. 206 (1): 1–10. doi:10.1006/excr.1993.1113. PMID 8482351.
Gillett GT, Fox MF, Rowe PS, et al. (1996). "Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14.". Ann. Hum. Genet. 60 (Pt 3): 201–11. PMID 8800436.
Okada K, Takano-Ohmuro H, Obinata T, Abe H (1996). "Dephosphorylation of cofilin in polymorphonuclear leukocytes derived from peripheral blood.". Exp. Cell Res. 227 (1): 116–22. doi:10.1006/excr.1996.0256. PMID 8806458.
Nebl G, Meuer SC, Samstag Y (1996). "Dephosphorylation of serine 3 regulates nuclear translocation of cofilin.". J. Biol. Chem. 271 (42): 26276–80. PMID 8824278.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Ott DE, Coren LV, Kane BP, et al. (1996). "Cytoskeletal proteins inside human immunodeficiency virus type 1 virions.". J. Virol. 70 (11): 7734–43. PMID 8892894.
Yang N, Higuchi O, Ohashi K, et al. (1998). "Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization.". Nature 393 (6687): 809–12. doi:10.1038/31735. PMID 9655398.
Rodal AA, Tetreault JW, Lappalainen P, et al. (1999). "Aip1p interacts with cofilin to disassemble actin filaments.". J. Cell Biol. 145 (6): 1251–64. PMID 10366597.
Maekawa M, Ishizaki T, Boku S, et al. (1999). "Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.". Science 285 (5429): 895–8. PMID 10436159.
Sumi T, Matsumoto K, Takai Y, Nakamura T (2000). "Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2.". J. Cell Biol. 147 (7): 1519–32. PMID 10613909.
Adachi R, Matsui S, Kinoshita M, et al. (2001). "Nitric oxide induces chemotaxis of neutrophil-like HL-60 cells and translocation of cofilin to plasma membranes.". Int. J. Immunopharmacol. 22 (11): 855–64. PMID 11090694.
Lee K, Jung J, Kim M, Guidotti G (2001). "Interaction of the alpha subunit of Na,K-ATPase with cofilin.". Biochem. J. 353 (Pt 2): 377–85. PMID 11139403.
Toshima J, Toshima JY, Amano T, et al. (2001). "Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation.". Mol. Biol. Cell 12 (4): 1131–45. PMID 11294912.
Sumi T, Matsumoto K, Shibuya A, Nakamura T (2001). "Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha.". J. Biol. Chem. 276 (25): 23092–6. doi:10.1074/jbc.C100196200. PMID 11340065.